Thermoregulation in animals

Novel Nano-vaccines for Melanoma /skin Cancer

Researchers have developed a novel Nano-vaccine for melanoma, the most aggressive type of skin cancer that begins in melanocytes. Their experiments have proven effective in preventing the development of melanoma and in treating primary tumours and metastases that result from melanoma. The focus of the research was on a nanoparticle that serves as the basis for the new vaccine. Melanoma develops in the skin cells, which is called the melanocytes, produce melanin or skin pigment. The fight against skin cancer/melanoma is becoming advanced over the years through a variety of treatment modalities & experiments, such as immunotherapy, radiation therapy & chemotherapy, but the vaccine approach, which has a great effect against various viral diseases, has not materialized yet against cancer. Scientists have shown that it is possible to produce an effective Nano-vaccine against melanoma/skin cancer and to sensitize the immune system to immunotherapies. The researchers harnessed ...

Phytochemicals: Curcumin, Resveratrol, Gallic acid, Glycyrrhizin, withinone, Colchicine, Andrographolide, Astaxanthin, Emodin

The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2, formerly known as 2019-nCoV, the causative pathogen of Coronavirus Disease 2019 (COVID-19) is a major source of disaster in the 21st century. In the second meeting of the Emergency Committee, the World Health Organization (WHO) declared that COVID-19 is a “public health emergency of international concern” On 30 January 2020. Coronavirus transmitted via airborne droplets from humans to humans or human to animal. Through membrane ACE-2 exopeptidase receptor coronavirus enters in human cells. For the treatment of this sudden and lethal disease during COVID-19, there are no specific anti-virus drugs or vaccines. Still, the development of these medicines will take months, even years. Currently, there is a need for supportive care and non-specific treatment to improve the symptoms of COVID-19 infected patients. For this specific indication, the rapid performance of Herbal medicine or Phytochemicals can contribute a...

New class of Antibiotics disrupts protein synthesis

Odilorhabdins: Odilorhabdins , or ODLs, a new class of antibiotics which disrupts protein synthesis are produced by symbiotic bacteria Xenorhabdus Nematophilia , found in soil-dwelling nematode worms that colonize insects for food. The bacteria Xenorhabdus Nematophilia actually helps to kill the insect and, importantly, secrete the antibiotic to keep competating the other bacteria away. Till now, these nematode-associated bacteria and the antibiotics they make have been largely understudied. To identify the antibiotic property present in the xenorhabdus bacteria, researchers screened 80 cultured strains of the bacteria & isolated the active compounds showing properties of antibiotics, studied their chemical structures and engineered more potent derivatives. ODLs mainly act on the ribosome, which is the molecular machine of individual cells that makes the proteins it needs to function of bacterial cells. Like many clinically useful antibiotics, O...

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